Welcome to the Wnt & β-Catenin Targeted Drug Development Summit

Turning Biology into Translational Insights to Support Clinical Development of Wnt/β-Catenin Candidates to Offer a Safe, Efficacious First-in-Class IO Therapy for Patients 

With an improved understanding of biology and mechanisms of action, the Wnt/β-Catenin community is surging through clinic in 2022 with positive clinical updates. The excitement of a potential first-in-class candidate to advent combination, immuno-oncology therapies in colorectal, head & neck and non-small cell lung cancer is offering hope for patients with high unmet medical needs.

After 2 decades of research, we are excited to see milestones reached within drug developers, including Tonix Pharmaceuticals targeting Wnt/ β-catenin pathway as a broad-spectrum antiviral strategy, Boehringer Ingelheim/Surrozen collaboration seeking retinal therapies along the Wnt pathway. It is now the time for drug developers to act and get together at the 2nd Wnt/β-Catenin Pathway Targeted Drug Development Summit. As the one and only industry-led meeting, you will be equipped with unparalleled insights in:

  • Wnt/β-Catenin’s structural biology and medicinal chemistry – turning the undruggable druggable
  • Comparison of different Wnt/β-Catenin modulation approaches, its interaction with TIL and tumor microenvironment for targeted, combination therapies
  • Translating basic science into clinical design – from scheduling to dosing, overcoming toxicity to widen the therapeutic window with safety in mind
  • Validating a clinical biomarker for patient selection

In collaboration with Wnt/β-Catenin pioneers such as Iterion Therapeutics, Leap Therapeutics, FogPharma, this is your unique opportunity to join and meet 60+ drug developers to forge long-term collaboration and advance Wnt/β-Catenin as a valuable target and clinical asset, propelling to provide first-in-class treatments for patients!

What can you expect to learn this year?

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Accelerate your Pipeline - Assess
the therapeutic potential of this
pathway across oncology by hearing from Acworth Pharma and Beatston Institute to build the latest knowledge into your R&D strategy

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Overcome Safety Concerns - Understanding what you can do within safety and scheduling, to reduce toxicity alongside short and long term impacts for clinical success with Iterion Therapeutics

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Novel Approaches - Examine novel
approaches in the Wnt pathway from Pfizer, Boston School of Medicine, and Pin Therapeutics, and dive into new modulation approaches and combination therapies

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Translational Insights - Learn about the newest preclinical advancements from MD Anderson and Fog Pharma, understand where cutting-edge development will take us into 2023

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Clinical Progress - Hear updates from the most recent clinical trials with Leap Therapeutics, Redx Pharma and Ohio State University deep-diving into their most recent results

Expert Speakers Include:

Gary Piazza


University of Auburn

Michele Jacob


Tufts University

Wenze Ma

Senior Scientist


Jack Leonard


Acworth Pharma

Previous Attendees:

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